Serum Brain-derived Neurotrophic Factor Levels Following Electroconvulsive Therapy in Treatment-resistant Depressed Patients
| Autor: | Oga Sasaki, Hisashi Higuchi, Noboru Yamaguchi, Mioto Maedomari, Toshiaki Haga, Takashi Nishio, Mitsuhiro Kamata |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Brain-derived neurotrophic factor
medicine.medical_specialty business.industry medicine.medical_treatment Patient response behavioral disciplines and activities Gastroenterology Electroconvulsive therapy Neurotrophic factors Internal medicine mental disorders Montgomery–Åsberg Depression Rating Scale medicine medicine.symptom Psychiatry Major depressive episode business Treatment resistant Depression (differential diagnoses) |
| Zdroj: | Journal of St. Marianna University. 6:253-261 |
| ISSN: | 2189-0277 2185-1336 |
| DOI: | 10.17264/stmarieng.6.253 |
| Popis: | Objectives: To determine whether serum levels of brain-derived neurotrophic factor (BDNF) are associated with response to electroconvulsive therapy (ECT) in treatment-resistant depressed patients with a relatively lon‐ ger period of measurement. Methods: This study included 30 Japanese unipolar depressed patients with current major depressive episode. Montgomery-Asberg Depression Rating Scale (MADRS) score was ≥21 in all subjects. ECT was performed twice a week for a total of 4–10 sessions. Serum BDNF levels were measured before ECT (T0), the day after the last ECT session (T1), and 1 month after the last ECT session (T2). Patient response to treatment was de‐ 昀ned as a ≥50% decrease compared with the pretreatment total MADRS score. Results: Serum BDNF levels showed no signi 昀cant variation among the patients during the entire study period. In responders, serum BDNF levels showed a progressive increase, and the differences between T0 and T1 and between T0 and T2 were signi 昀cant (p=0.022 and p=0.007, respectively). In non-responders, serum BDNF lev‐ els showed a progressive decrease, and the difference between T0 and T2 was signi 昀cant (p=0.012). No signi 昀† cant association was identi 昀ed between change in serum BDNF level and change in total MADRS score in any of the patients following ECT. Conclusions: The present results showed that serum BDNF levels after ECT increased progressively in res‐ ponders, but not in non-responders. Our results provide important information for understanding the exact role of BDNF in the antidepressive effects of ECT. |
| Databáze: | OpenAIRE |
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