O4‐03‐03: What is a normal change in memory? n=1 classification of clinically relevant cognitive decline
| Autor: | Jennifer H. Barnett, Mathew J. Summers, Francesca Cormack, Shannon Z. Klekociuk, Andrew D. Blackwell, Pradeep J. Nathan, Nikki L. Saunders |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Epidemiology Health Policy Cognition Audiology medicine.disease Cognitive test Developmental psychology Psychiatry and Mental health Cellular and Molecular Neuroscience Developmental Neuroscience mental disorders medicine Dementia Neurology (clinical) Neuropsychological assessment Effects of sleep deprivation on cognitive performance Geriatrics and Gerontology Cognitive decline Psychology Pathological Episodic memory |
| Zdroj: | Alzheimer's & Dementia. 11 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Background: Clinicians often have to decide whether a person’s reported or measured change in cognition reflects normal aging or clinically-relevant cognitive decline. For most cognitive tests, there is no evidence-based guidance for how much change is ‘normal’ over a given timeframe. This study aimed to statistically determine the limits of clinically-significant memory change among healthy older adults and those with mild cognitive impairment (MCI). Methods: Longitudinal cognitive performance was examined in 21 healthy older adults and 81 individuals with clinically-defined MCI. Participants were assessed on Cantab Paired Associate Learning (PAL), a non-verbal episodic memory test, at baseline, 10 months and 20 months as part of a comprehensive neuropsychological assessment. They were classified as amnestic-MCI if there was a deficit (performance |
| Databáze: | OpenAIRE |
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