Large-Scale Preparation of [13C]Methyl Phenyl Sulfide from [13C]Methanol by a One-Step Process

Autor:	Marc A. Alvarez, Louis A. Silks, Philip L. Stotter, Rodolfo A. Martinez, Jurgen G. Schmidt, Clifford J. Unkefer, Stephen P. Velarde
Rok vydání:	2002
Předmět:	chemistry.chemical_compound chemistry Deuterium Phenyl sulfide Organic Chemistry Organic chemistry One-Step Methanol Physical and Theoretical Chemistry Medicinal chemistry Sulfone Methyl iodide
Zdroj:	Organic Process Research & Development. 6:851-854
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op025530p
Popis:	We have developed a large-scale “one-pot” procedure for the conversion of commercially available [13C]- or [2H3,13C]methanol to [13C]- or [2H3,13C]methyl phenyl sulfide. [13C]methyl phenyl sulfide is a potentially versatile, chemically stable, and nonvolatile labeling precursor. In addition, we report an efficient method for the oxidation of [13C]methyl phenyl sulfide to [13C]methyl phenyl sulfone. Finally, we have used [13C]methyl phenyl sulfide to produce 13C-labeled methyl iodide, containing exactly one or two deuterons.
Databáze:	OpenAIRE
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