Association Between Serum Antibodies to Periodontal Bacteria and Rheumatoid Factor in the Third National Health and Nutrition Examination Survey
| Autor: | Jerry A. Molitor, Charlene E. Goh, Ryan T. Demmer, Panos N. Papapanou, Jacob Kopp |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty education.field_of_study National Health and Nutrition Examination Survey biology Cross-sectional study business.industry Immunology Population Prevotella intermedia 030206 dentistry Odds ratio biology.organism_classification Periodontal pathogen 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Immunology and Allergy Population study Rheumatoid factor education business |
| Zdroj: | Arthritis & Rheumatology. 68:2384-2393 |
| ISSN: | 2326-5191 |
| Popis: | Objective Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (Porphyromonas gingivalis), and are not population based. This study was undertaken to investigate the association between elevated serum levels of IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults. Methods The Third National Health and Nutrition Examination Survey (NHANES-III) is a cross-sectional sample of the noninstitutionalized US population (n = 33,994). Our study population included all dentate participants who were 60 years and older, did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n = 2,461). Results Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) summarizing the relationship between the 19 periodontal serum IgG antibodies and RF seropositivity ranged from 0.53 (95% CI 0.29–0.97) to 1.27 (95% CI 0.79–2.06), and 17 of the 19 observed ORs were |
| Databáze: | OpenAIRE |
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