Protein Kinases A and C are Involved in Oligodendroglial Process Formation
| Autor: | Peter Schwartz, Volker Neuhoff, J. Schröter, H. H. Althaus, Sabine Klöppner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
0303 health sciences
Chemistry Kinase Regeneration (biology) Protein Data Bank (RCSB PDB) Receptor-mediated endocytosis Regenerative process Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Remyelination Protein kinase A 030217 neurology & neurosurgery Protein kinase C 030304 developmental biology |
| Zdroj: | Cellular and Molecular Biology of Myelination ISBN: 9783642839702 |
| DOI: | 10.1007/978-3-642-83968-9_17 |
| Popis: | Oligodendrocytes (Ol), shorn of their processes during the isolation procedure, regenerate their fibres under appropriate culture conditions (Althaus et al., 1984). various diffusible and non-diffusible compounds contribute to this regenerative process. Some of the signaling factors seem to be receptor mediated and transduced via the protein kinases. Activation of protein kinase C by phorbol esters such as tetradecanoylphorbolacetate (TPA) or 4-β phorboldibutyrate (4-β PDB) enhanced the oligodendroglial fibre formation appreciably, as revealed by phase contrast microscopy (Schroter and Althaus, 1987). However, a closer insight into the sequence of oligodendroglial process regeneration was obtained by using scanning electron microscopy (SEM). This showed that activation of protein kinase A (Pk-A) and protein kinase C (Pk-C) supports different steps of the initial remyelination process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|