Vascularites cutanées leucocytoclasiques: à propos de 85 cas
| Autor: | Najet Ghariani, Mohamed Denguezli, Badreddine Sriha, Wafa Saidi, Rafia Nouira, Amina Aounallah, Colandane Belajouza, Aicha Arouss |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Anti-nuclear antibody business.industry Cross-sectional study Medical record Retrospective cohort study General Medicine 030204 cardiovascular system & hematology medicine.disease Rash Dermatology Cryoglobulinemia 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Epidemiology Etiology Medicine medicine.symptom business |
| Zdroj: | Pan African Medical Journal. 26 |
| ISSN: | 1937-8688 |
| DOI: | 10.11604/pamj.2017.26.138.9721 |
| Popis: | Clinical manifestation, etiology and outcome of leukocytoclastic vasculitis are little studied. The aim of our study was to examine epidemiological, clinical etiological, and evolutionary characteristics of this entity. We conducted a cross-sectional data collection from medical records of 85 patients with leukocytoclastic vasculitis in the Department of Dermatology at the Farhat Hached University Hospital, Sousse between January 2000 and December 2013. Epidemiological, clinical, paraclinical, etiological data sheets had been completed for each patient. The average age of patients was 47.65 years, ranging between 10 and 78 years. Fifty-three women and 32 men were registered (sex ratio = 0.6). Cutaneous manifestations were dominated by vascular purpura (88.2%). The most common causes of leukocytoclastic vasculitis were systemic diseases (51%), infection (20%) and neutrophilic dermatoses (14.5%). Other causes were drugs (9.1%) and hematologic malignancies (5.4%). The cause of leukocytoclastic vasculitis was not detected in 30 patients (35, 3%). Two predictive factors associated with the acute outcome were retained: the presence of a recent infection (p= 0.014) and drug intake before the rash (p= 0.013). Chronic evolution was positively correlated with antinuclear antibodies (p= 0.009) and cryoglobulinemia (p=0.025). Our study highlights the multitude of causes of leukocytoclastic vasculitis. The search for an underlying disease is an imperative in order to ensure better therapeutic management. |
| Databáze: | OpenAIRE |
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