The Effect of Rutin on Antioxidant and Anti-inflammation in Streptozotocin-induced Diabetic Rats
| Autor: | Yoon Jeong Lee, Kyung Hee Jeune |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Kidney Antioxidant endocrine system diseases medicine.medical_treatment nutritional and metabolic diseases Inflammation General Medicine Streptozotocin Rutin chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Vacuolization Internal medicine medicine Histopathology medicine.symptom Pancreas medicine.drug |
| Zdroj: | Applied Microscopy. 43:54-64 |
| ISSN: | 2287-5123 |
| DOI: | 10.9729/am.2013.43.2.54 |
| Popis: | The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, -cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats. |
| Databáze: | OpenAIRE |
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