Modelling and control of combined cooling and antisolvent crystallization processes
| Autor: | Mitsuko Fujiwara, Richard D. Braatz, Zoltan K. Nagy |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Population balance model
business.industry Computer science Process analytical technology Control (management) Combined technique Optimal control Industrial and Manufacturing Engineering Combined approach Computer Science Applications law.invention Control and Systems Engineering law Modeling and Simulation Crystallization Process engineering business |
| Zdroj: | Journal of Process Control. 18:856-864 |
| ISSN: | 0959-1524 |
| DOI: | 10.1016/j.jprocont.2008.06.002 |
| Popis: | Although for decades nearly all pharmaceuticals have been purified by crystallization, there have been a disproportionate number of problems associated with the operation and control of these processes. This paper provides an overview of the recent advances in model-based and model-free (direct design) approaches to control the crystallization of pharmaceuticals, treating both antisolvent and cooling crystallization. A model-based combined technique which simultaneously controls the antisolvent addition rate and the cooling profile is presented. A population balance model of the combined cooling-antisolvent addition system is developed and a moments model is used in optimal control strategies with various objective functions. The simulation and experimental results show the advantages of the combined approach. |
| Databáze: | OpenAIRE |
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