Literature on Fetal Therapy on Interatrial Septum
| Autor: | Simona Anna Marcora |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Lung business.industry medicine.medical_treatment Foramen secundum Primary interatrial foramen medicine.disease Pulmonary vein Hypoplastic left heart syndrome medicine.anatomical_structure Internal medicine cardiovascular system medicine Cardiology cardiovascular diseases Atrial septostomy business Pulmonary vein stenosis Interatrial septum |
| Zdroj: | Fetal and Hybrid Procedures in Congenital Heart Diseases ISBN: 9783319400860 |
| Popis: | Atrial septal restriction during fetal age is widely recognized as a lethal defect mostly in patients with hypoplastic left heart syndrome (HLHS) and intact atrial septum (IAS) or highly restrictive atrial septum (HRAS). The poor outcome has been attributed to structural abnormalities of the pulmonary venous vasculature with arterialization of pulmonary veins and dilatation of lymphatics due to prenatal left atrial hypertension [1]. This hypothesis has been recently supported by an interesting histopathologic study on changes in alveoloseptal lung parenchyma in fetuses with atrial septal restriction; these authors observed that severe lung disease is already evident in the second trimester, precisely in week 23 [2]. Efforts to decompress the hypertensive left atrium in utero have been made since 2000 to treat neonatal hypoxia and hemodynamic instability, to improve anatomic lung abnormalities and outcome. This chapter is a review of the most significant experiences reported in literature on procedural and clinical results of fetal atrial septostomy procedures in HLHS and IAS/HRAS. |
| Databáze: | OpenAIRE |
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