Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines

Autor:	Tahia B. Mostafa, Emtithal A. El-Sawi, Hyam A. Radwan
Rok vydání:	2011
Předmět:	chemistry.chemical_compound chemistry biology Stereochemistry Isatin Proton NMR Biological activity Bacillus subtilis Carbon-13 NMR Triphenylphosphine biology.organism_classification Antibacterial activity Triethylphosphite
Zdroj:	European Journal of Chemistry. 2:539-543
ISSN:	2153-2257 2153-2249
DOI:	10.5155/eurjchem.2.4.539-543.55
Popis:	Isatin-3-imine derivatives ( 1a - d ) have been synthesized. These compounds were then converted into phosphorylated products 2a , 2c with triethylphosphite and 3a - d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1 H NMR, 13 C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b - d and 3c - d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli . Compound 3a was found to exhibit antifungal activity against the tested organisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4559ca6c84bfc7b3df273bf8d3f1d14 https://doi.org/10.5155/eurjchem.2.4.539-543.55 Zobrazit plný text záznamu