Thermal studies of furosemide–caffeine binary system that forms a cocrystal

Autor:	Sulur G. Manjunath, B. N. Roopa, Khalid Abu, Sudhir Nambiar, Sharmistha Pal
Rok vydání:	2013
Předmět:	Phase transition Crystallography chemistry.chemical_compound Differential scanning calorimetry Chemistry Phase (matter) Binary system Physical and Theoretical Chemistry Condensed Matter Physics Caffeine Cocrystal Eutectic system Phase diagram
Zdroj:	Journal of Thermal Analysis and Calorimetry. 115:2261-2268
ISSN:	1588-2926 1388-6150
Popis:	Thermal techniques, differential scanning cal- orimetry (DSC), and hot stage microscopy (HSM) have been used to study the interactions between furosemide and caffeine that are known to form a 1:1 cocrystal. This sys- tem has been used as an example to study the probable mechanism of cocrystal formation when the individual components, which are polymorphic, are heated. The study indicates that the phase transition of the low temperature stable polymorph of furosemide initiates cocrystal forma- tion. This result suggests increased mass transfer rate can trigger cocrystal formation. The binary phase diagram (composition-temperature plots) of furosemide-cocrystal- caffeine system was determined from the DSC curves. The results imply that the cocrystal forms eutectic with caffeine but not with furosemide. This study has thus exemplified the use of DSC in understanding binary phase system where the two components form a cocrystal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b44a3362404cdc07e0dd3ec525cb2ddf https://doi.org/10.1007/s10973-013-3031-5 Zobrazit plný text záznamu Full text from SpringerLink