Application of DSC and NIRS to study the compatibility of metronidazole with different pharmaceutical excipients

Autor:	Romána Zelkó, Cs. Novák, Zs. Éhen, Dorottya Kiss
Rok vydání:	2006
Předmět:	Materials science Ethylene oxide Inorganic chemistry Excipient Condensed Matter Physics Dosage form Microcrystalline cellulose chemistry.chemical_compound Differential scanning calorimetry chemistry medicine Anhydrous Physical and Theoretical Chemistry Hydrate Thermal analysis medicine.drug
Zdroj:	Journal of Thermal Analysis and Calorimetry. 84:447-451
ISSN:	1572-8943 1388-6150
DOI:	10.1007/s10943-005-7257-9
Popis:	The purpose of the present work was to study the compatibility of metronidazole with different pharmaceutical excipients (hydroxypropyl methylcellulose, poly(ethylene oxide), microcrystalline cellulose, dicalcium phosphate dihydrate, and anhydrous dicalcium phosphate) using differential scanning calorimetry and diffuse reflectance spectroscopy. Dicalcium phosphate dihydrate was the only excipient that showed interaction with metronidazole even before storage. Changes referring to a possible transition to dihydrate form were observed in the thermal curves of anhydrous dicalcium phosphate after four weeks of storage. Although dicalcium phosphate dihydrate can be replaced by the anhydrous form in pharmaceutical formulations, the observed transition might negatively influence the stability of dosage forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b44a0fc15a96a19bd4096c368ccd113d https://doi.org/10.1007/s10943-005-7257-9 Zobrazit plný text záznamu Plný text ve formátu PDF