In Vitro Intraductal MRI and T2 Mapping of Cholangiocarcinoma Using Catheter Coils

Autor: Simon D. Taylor-Robinson, Christopher A. Wadsworth, Attapol Titapun, Prakasit Sa-Ngiamwibool, Nittaya Chamadol, Shuo Zhang, Wuttisak Boonphongsathien, Evdokia M. Kardoulaki, Narong Khuntikeo, Richard R. A. Syms
Rok vydání: 2020
Předmět:
Zdroj: Hepatic Medicine: Evidence and Research. 12:107-114
ISSN: 1179-1535
DOI: 10.2147/hmer.s266841
Popis: Aim Diagnostic imaging of early-stage cholangiocarcinoma is challenging. A previous in vitro study of fixed-tissue liver resection specimens investigated T2 mapping as a method of exploiting the locally increased signal-to-noise ratio (SNR) of duodenoscope coils for improved quantitative magnetic resonance imaging (MRI), despite their non-uniform sensitivity. This work applies similar methods to unfixed liver specimens using catheter-based receivers. Methods Ex vivo intraductal MRI and T2 mapping were carried out at 3T on unfixed resection specimens obtained from cholangiocarcinoma patients immediately after surgery using a catheter coil based on a thin-film magneto-inductive waveguide, inserted directly into an intrahepatic duct. Results Polypoid intraductal cholangiocarcinoma was imaged using fast spin-echo sequences. High-resolution T2 maps were extracted by fitting of data obtained at different echo times to mono-exponential models, and disease-induced changes were correlated with histopathology. An increase in T2 was found compared with fixed specimens and differences in T2 allowed the resolution of tumour tissue and malignant features such as polypoid morphology. Conclusion Despite their limited field of view, useful data can be obtained using catheter coils, and T2 mapping offers an effective method of exploiting their local SNR advantage without the need for image correction.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje