Immunocytochemical analysis of the disturbances in the structure of synaptonemal complexes in spermatocyte nuclei in mice under exposure to rocket fuel component
| Autor: | A. V. Lovinskaya, S. K. Abilev, Kolumbayeva SZh, Oxana Kolomiets |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Autosome
integumentary system Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine Spermatocyte Anatomy Biology Pollution Bivalent (genetics) Cell biology Synaptonemal complex medicine.anatomical_structure nervous system Meiosis medicine Dimethylhydrazine Immunohistochemistry Stem cell tissues |
| Zdroj: | Hygiene and sanitation. 95:293-296 |
| ISSN: | 2412-0650 0016-9900 |
| DOI: | 10.18821/0016-9900-2016-95-3-293-296 |
| Popis: | There was performed an assessment of genotoxic effects of rocket fuel component--unsymmetrical dimethylhydrazine (UDMH, heptyl)--on forming germ cells of male mice. Immunocytochemically there was studied the structure of meiotic nuclei at different times after the intraperitoneal administration of UDMH to male mice. There were revealed following types of disturbances of the structure of synaptonemal complexes (SCs) of meiotic chromosomes: single and multiple fragments of SCs associations of autosomes with a sex bivalent, atypical structure of the SCs with a frequency higher than the reference level. In addition, there were found the premature desinapsis of sex bivalents, the disorder offormation of the genital corpuscle and ring SCs. Established disorders in SCs of spermatocytes, analyzed at 38th day after the 10-days intoxication of animal by the component of rocket fuel, attest to the risk of permanent persistence of chromosomal abnormalities occurring in the pool of stem cells. |
| Databáze: | OpenAIRE |
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