Preparation of novel bio-matrix by the complexation of DNA and metal ions
| Autor: | Motoyoshi Nomizu, Shuya Satoh, Masanori Yamada, Norio Nishi, Miho Yokota, Michiko Kaya, Benjamas Jonganurakkun |
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| Rok vydání: | 2005 |
| Předmět: |
inorganic chemicals
Aqueous solution Polymers and Plastics Hydroquinone Stereochemistry Metal ions in aqueous solution Organic Chemistry Inorganic chemistry Ascorbic acid Benzoquinone Ion Metal chemistry.chemical_compound chemistry visual_art Materials Chemistry visual_art.visual_art_medium Qualitative inorganic analysis |
| Zdroj: | Polymer. 46:10102-10112 |
| ISSN: | 0032-3861 |
| DOI: | 10.1016/j.polymer.2005.07.086 |
| Popis: | Large amounts of DNA-enriched biomaterials, such as salmon milts and shellfish gonads, are discarded as industrial waste around the world. We could convert the discarded DNA into a novel bio-matrix by the hybridization of DNA and metal ions, such as Al3+, Cr3+, Fe2+, Fe3+, Cu+, Cu2+, Zn2+, and Cd2+. These water-insoluble DNA-metal ion matrices could be created in various desirable forms, such as a gel, capsule, film, or fiber. DNA-Al3+ matrices were found to maintain a B-form DNA structure, which was the native double-stranded DNA structure in water. The DNA-Al3+ fiber showed flexibility with the molecular orientation in the direction of drawing. When a DNA-Cu2+ matrix was incubated in an aqueous hydroquinone or ascorbic acid solution, benzoquinone or dehydroascorbic acid was produced, respectively, by the oxidative effect of Cu2+ in the DNA-metal ion matrix. These results suggest that metal ions in the DNA-metal matrix maintained the oxidative function. The water-insoluble DNA-metal ion matrices may have a potential utility as a functional bio-material, such as an antibacterial, oxidative, bio-sensor, and ion conductive materials. |
| Databáze: | OpenAIRE |
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