The Rationale and Design of the CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) Trial
| Autor: | Grace Peng, Douglas L. Mayers, Barbara Brizz, Li Chen, C. Lynn Besch, Mary van den Berg-Wolf, Teresa Yurik, Barry Schmetter, Rodger D. MacArthur, Richard M. Novak, Donald I. Abrams |
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| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Research design medicine.medical_specialty business.industry Clinical study design Human immunodeficiency virus (HIV) medicine.disease_cause medicine.disease Antiretroviral therapy law.invention Clinical trial Clinical research Randomized controlled trial Acquired immunodeficiency syndrome (AIDS) law Family medicine Immunology medicine business |
| Zdroj: | Controlled Clinical Trials. 22:176-190 |
| ISSN: | 0197-2456 |
| DOI: | 10.1016/s0197-2456(01)00111-8 |
| Popis: | The CPCRA (Terry Beirn Community Programs for Clinical Research on AIDS) 058 FIRST (Flexible Initial Retrovirus Suppressive Therapies) trial is a large, long-term, randomized, prospective comparison of three different antiretroviral strategies in highly active antiretroviral therapy-naive, HIV-1-infected persons. The trial was designed as a flexible framework upon which other studies could be added to answer more limited, but still important, questions. This article presents the study design, discusses the challenges we have faced in implementing the trial, and describes our preliminary experiences. Control Clin Trials 2001;22:176-190 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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