Piroxicam and doxycycline treatment for an oral squamous cell carcinoma in an inshore bottlenose dolphin (Tursiops aduncus)
| Autor: | DT March, GD Bossart, DJ Blyde, AP Begg, DP Taylor, V McClure |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty 040301 veterinary sciences Piroxicam Malignant transformation 0403 veterinary science 03 medical and health sciences Tongue Biopsy medicine Tursiops aduncus Doxycycline General Veterinary biology medicine.diagnostic_test 04 agricultural and veterinary sciences General Medicine biology.organism_classification medicine.disease Bottlenose dolphin stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Papilloma medicine.drug |
| Zdroj: | Australian Veterinary Journal. 94:203-207 |
| ISSN: | 0005-0423 |
| Popis: | Background The virus family Papillomaviridae has been documented in a wide range of animal species and can cause benign and malignant proliferative lesions. The presence of concurrent lingual papillomas and squamous cell carcinomas (SCC) in cetaceans has also been documented in both wild and captive populations, suggesting malignant transformation of benign papilloma to SCC may occur in this species. Case report In 2008, a 38-year-old captive male inshore bottlenose dolphin (Tursiops aduncus) was diagnosed with papillomatous lesions on the intermandibular frenulum rostral to the tongue and an infiltrative SCC of the soft palate following biopsy and histological analysis. A treatment regimen of piroxicam and doxycycline was initiated with misoprostol as a gastroprotectant. The treatment resulted in a marked reduction in tumour size and reversible hepatotoxicosis. Subsequent biopsies revealed the presence of SCC in the oral cavity; however, the disease remains stable at the time of writing. Conclusion To the best of our knowledge, this case is the first report of piroxicam and doxycycline used to treat SCC in a bottlenose dolphin. The treatment was successful in reducing the clinical presentation of the disease. |
| Databáze: | OpenAIRE |
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