Synthesis, annulation, and heterofunctionalization of 4-hydrazinylpyrazolo[1,5-а]pyrazines

Autor:	Yevhenii V. Hrynyshyn, M. V. Vovk, Nazar M. Tsizorik, Anna R. Musiychuk, Nadezhda V. Panasenko, A. V. Bol’but
Rok vydání:	2018
Předmět:	Annulation 010405 organic chemistry Phenyl isothiocyanate Acetylacetone Organic Chemistry 010402 general chemistry Triethyl orthoformate 01 natural sciences Medicinal chemistry 0104 chemical sciences Acetic anhydride chemistry.chemical_compound chemistry Ethyl chloroformate Tetrazole Malononitrile
Zdroj:	Chemistry of Heterocyclic Compounds. 54:710-716
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-018-2337-4
Popis:	4-Hydrazinylpyrazolo[1,5-а]pyrazines were obtained by reactions of 4-chloropyrazolo[1,5-а]pyrazines with hydrazine hydrate and further combined with compounds having one reactive site (triethyl orthoformate, acetic anhydride, ethyl chloroformate, phenyl isothiocyanate, hydrazoic acid) or two reactive sites (diethyl oxalate), forming the respective derivatives containing fused 1,2,4-triazole, tetrazole, or 1,2,4-triazine rings. The reactions with acetylacetone and ethoxymethylene derivatives of malononitrile or ethyl cyanoacetate were used to synthesize 4-(1-pyrazolyl)-substituted pyrazolo[1,5-а]pyrazines.
Databáze:	OpenAIRE
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