Crucial Reactions for Salt Tolerance in Yeast

Autor: Consuelo Montesinos, Gabino Ríos, José A. Márquez, Pedro L. Rodriguez, Carlos Romero, Roberto Gaxiola, Vicente J. Miralles, Francisco A. Culiáñez-Macià, José Ramón Murguía, Rashid Ali, Alejandro Ferrando, María José García, Ramón Serrano, Ana Espinosa, Françoise Montrichard, Heinz-U. Gläser
Rok vydání: 1996
Předmět:
Zdroj: Physical Stresses in Plants ISBN: 9783642647321
DOI: 10.1007/978-3-642-61175-9_10
Popis: Random over-expression of genes in multicopy plasmids and gene disruptions have uncovered rate-limiting steps for salt tolerance in the model organism Saccharomyces cerevisiae (baker’s yeast). In cells growing in glucose media intracellular sodium toxicity is the major component of salt stress. In minimal synthetic media sodium toxicity primarily affects methionine biosynthesis. This is due to sodium inhibition of the 3′,5′-bisphosphate nucleotidase encoded by the HAL2/MET22 gene. The sodium-extrusion ATPase encoded by the ENA1/PMR2 gene is the major determinant of sodium homeostasis, together with its complex regulatory system, which includes the calcineurin and HAL3 (HAL1) pathways.
Databáze: OpenAIRE