Effect of Iloprost (E-1030), A Stable Analogue of Prostacyclin, on Haemorheology and Hemostasis in Peripheral Arterial Occlusive Disease

Autor:	Nobuko Tsushima, Hiroshi Matsuo, Katsuhiko Hiramori
Rok vydání:	1992
Předmět:	business.industry Peripheral arterial occlusive disease Hemostasis Anesthesia Medicine Platelet Prostacyclin business Fibrinogen Microcirculation medicine.drug Whole blood Iloprost
Zdroj:	Japanese Journal of Thrombosis and Hemostasis. 3:427-434
ISSN:	1880-8808 0915-7441
DOI:	10.2491/jjsth.3.427
Popis:	Whole blood viscosity, plasma viscosity, whole blood and plasma passage time were all significantly decreased and shortened compared to pre-drug values after intravenously administered Iloprost, a stable analogue of prostacyclin, to patients with peripheral arterial occlusive disease at a flow rate of 1ng/kg/min for 30 minutes once a day for seven consecutive days.Plasminogen, antithrombin-III (ATIII) and α2-macroglobulin were significantly decreased along with inhibited platelet aggregation.When Iloprost was administered once a day for 6 consecutive days, whole blood viscosity at low shear rate and fibrinogen were decreased significantly.These findings suggest that Iloprost inhibits not only platelet aggregaton, but also stimulates fibrinolytic activity of blood and enhances blood fluidity and ameliorates microcirculation in the ischemic leg of patients with peripheral arterial occlusive disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b4087b900389b2a6f9a2d5f76145b747 https://doi.org/10.2491/jjsth.3.427 Zobrazit plný text záznamu