Systematic evaluation of microangiopathy in diabetic Chinese hamsters
| Autor: | G. A. Sawada, T. Peterson, G. C. Gerritsen, M. C. Blanks, Thomas J. Vidmar, A. R. Diani, Beatrice M. Wyse |
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| Rok vydání: | 1986 |
| Předmět: |
Basement membrane
medicine.medical_specialty biology Glomerular basement membrane Microangiopathy Hamster Cell Biology medicine.disease biology.organism_classification Biochemistry Chinese hamster Lesion Diabetic nephropathy Endocrinology medicine.anatomical_structure Diabetes mellitus Internal medicine medicine medicine.symptom Cardiology and Cardiovascular Medicine |
| Zdroj: | Microvascular Research. 31:306-316 |
| ISSN: | 0026-2862 |
| DOI: | 10.1016/0026-2862(86)90019-1 |
| Popis: | Renal glomeruli of 11- to 15- and 19- to 23-month-old nondiabetic (M) and diabetic (XA and AC) genetic sublines of Chinese hamsters were morphometrically analyzed to determine if minimal capillary basement membrane thickening (CBMT) is a microvascular complication in this animal model. Minimal glomerular capillary basement membrane thickness was significantly elevated in the AC diabetic subline (117.2 nm ± 5.0, P < 0.004) compared with the M nondiabetic subline (99.0 nm ± 14.0) in the 11- to 15-month age span. However, in the 19- to 23-month age range, both the XA (140.2 nm ± 20.0, P < 0.02) and AC (140.1 nm ± 12.4, P < 0.04) diabetic sublines displayed significantly greater glomerular capillary basement membrane thickness in comparison with the M nondiabetic subline (119.0 nm ± 13.4). The greatest influence on CBMT in the diabetics was shown to be a combination of the aging process and severity of hyperglycemia. This initial systematic morphometric study has demonstrated that glomerular CBMT is a characteristic microvascular lesion in 11- to 15-month-old diabetic AC and 19- to 23-month-old diabetic XA and AC Chinese hamsters in comparison with age-matched nondiabetics. Furthermore, this investigation suggests that the Chinese hamster appears to be an acceptable model for the study of chronic complications associated with diabetic nephropathy. |
| Databáze: | OpenAIRE |
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