Antidiarrheal Activity Test of White Pomegranate (Punica granatum L.) Infusion on Swiss Webster Male with Oleum Ricini Method

Autor:	Siti Nuurul Hidayah Assyifa, Ira Rahmiyani, Nur Rahayuningsih
Rok vydání:	2021
Předmět:	SWISS WEBSTER Stool consistency Traditional medicine biology business.industry Diarrhea Frequency Positive control biology.organism_classification Diarrhea Oleum ricini Punica Medicine medicine.symptom business Feces
Zdroj:	JURNAL ILMU KEFARMASIAN INDONESIA. 19:62
ISSN:	2614-6495 1693-1831
DOI:	10.35814/jifi.v19i1.943
Popis:	Diarrhea is a condition in which a person defecates with a soft or liquid consistency, which can evenbe water. Diarrhea can be treated with drugs derived from plants, one of which is white pomegranate skin. Theskin of white pomegranate (Punica granatum L.) is thought to have anti-diarrheal activity because it has fl avonoidsand tannins. This study aims to determine the activity and optimal dose of pomegranate skin infusion.Mice were grouped into 5 groups: negative control (Na CMC 0.5%), positive control (Loperamid HCl), andpomegranate peel infusion test group with a dose of 8 mg / 20 g mice BW, 16 mg / 20 g weight mice and 32 mg./ 20 gr BB mouse. Mice induced diarrhea with Oleum ricini, 30 minutes later the mice were given a test preparation.The onset of diarrhea, stool consistency, diarrhea frequency, duration of diarrhea and stool weight weremeasured every 30 minutes for 6 hours. The results showed that the fi rst dose (8 mg / 20 gr BW of mice) wasthe optimal dose for the initial parameters of diarrhea and fecal weight, which means that there was a signifi cantdiff erence with negative control and positive control ( 0, 05).
Databáze:	OpenAIRE
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