Attenuation of pressor response to laryngoscopy and intubation: Dexmedetomidine Vs. fentanyl premedication
| Autor: | Ravindra Kumar Gehlot, Madhan Chandramohan, Apoorva Aseri, Lalit Kumar Raiger, Gokulakrishnan L |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.diagnostic_test
business.industry medicine.medical_treatment Laryngoscopy 030208 emergency & critical care medicine Fentanyl 03 medical and health sciences 0302 clinical medicine Blood pressure 030202 anesthesiology Anesthesia Medicine Intubation General anaesthesia Premedication Airway management Dexmedetomidine business medicine.drug |
| Zdroj: | Indian Journal of Clinical Anaesthesia. 5:486-490 |
| ISSN: | 2394-4994 2394-4781 |
| DOI: | 10.18231/2394-4994.2018.0093 |
| Popis: | Introduction: The pressor response during laryngoscopy and intubation is part of a huge spectrum of stress response, results from the increase in sympathetic and sympatho-adrenal activity. The present study was planned to observe the attenuation of pressor response during laryngoscopy and intubation with dexmedetomidine and fentanyl; also to compare the effectiveness between these two drugs. Materials and Methods: In this study we include 128 patients, of ASA grade I- II, aged 18- 65yrs, of either gender, scheduled for elective surgery under general anaesthesia. Groups: Group D – Dexmedetomidine (0.6µg/kg) and Group F – Fentanyl (2µg/kg), these drugs diluted with NS to make 10 ml, given I.V. slow over 10 min. Vital parameters (HR, SBP, DBP and MBP) were recorded as baseline, then at 10 minutes after pre-medication and then at 1,2,3,5,7 and 10 minutes after endotracheal intubation. Results: There was significant increase in heart rate, systolic blood pressure and diastolic blood pressure during laryngoscopy and intubation in group F as compared to group D (p Conclusion: Dexmedetomidine (0.6mcg/kg) is superior to fentanyl (2mcg/kg) in the attenuation of the pressor response and that the ideal time for its administration should be about 10 minutes before a laryngoscopy and intubation. Keywords: Dexmedetomidine, Fentanyl, Intubation, Laryngoscopy, Pressor response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|