Preventive Effects of Saldi tierra Containing Various Trace Elements on Bone Loss in Rats with Diabetes or Adjuvant Arthritis
| Autor: | Shigeo Kouno, Masayoshi Yamaguchi, Satoshi Uchiyama |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Triglyceride Health Toxicology and Mutagenesis chemistry.chemical_element Calcium Toxicology Streptozotocin medicine.disease chemistry.chemical_compound Endocrinology chemistry In vivo Oral administration Internal medicine Diabetes mellitus medicine Alkaline phosphatase Adjuvant arthritis medicine.drug |
| Zdroj: | Journal of Health Science. 53:202-208 |
| ISSN: | 1347-5207 1344-9702 |
| Popis: | The preventive effect of Saldi tierra containing various trace elements on bone loss which is induced in rats with diabetes or adjuvant arthritis were investigated. Rats received a single subcutaneous administration of streptozotocin (STZ) (6.0 mg/100 g body weight), and the animals were orally administered a solution of Saldi tierra (25 or 50 mg/100 g) once daily for 14 days. STZ-administered rats caused a significant increase in serum glucose, triglyceride, or calcium levels and a significant decrease in body weight or serum inorganic phosphorus levels. These alterations were significantly restored after the oral administration of Saldi tierra .T he femoral-diaphyseal and -metaphyseal calcium contents were significantly decreased in STZ-diabetic rats. This decrease was significantly inhibited after the administration of Saldi tierra (25 or 50 mg/100 g). The decreases in diaphyseal and metaphyseal alkaline phosphatase activity and metaphyseal DNA content were significantly prevented after the administration of Saldi tierra (50 mg/100 g). Meanwhile, rats received an injection of 1% Mycobacterium butyricum suspension into the subplantar surface of the right hind paw, and the animals were orally administered Saldi tierra (50 mg/100 g) once daily for 18 days. Calcium content, alkaline phosphatase activity, and DNA content in the femoral-metaphyseal tissues were significantly decreased in rats with adjuvant arthritis. These decreases were significantly inhibited after the administration of Saldi tierra (50 mg/100 g). This study demonstrates that the intake of Saldi tierra has preventive effects against bone loss in rats with diabetes or adjuvant arthritis in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|