Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach
| Autor: | Rik Van Deun, Henk Vrielinck, Koen Muylaert, Lise Dereu, Matthias D'hooghe, Cedric Maton, Thomas Harth, Christian V. Stevens, Frederique Taillieu, Rob De Vreese |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Stereochemistry Organic Chemistry 8-Hydroxyquinoline 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Coupling reaction 0104 chemical sciences Coupling (electronics) chemistry.chemical_compound Drug Discovery Hydroxyquinolines Aminoquinolines |
| Zdroj: | Tetrahedron Letters. 58:3803-3807 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.08.039 |
| Popis: | Bis-8-hydroxyquinolines represent an important yet underexplored class of potential ligands for the preparation of various coordination polymers, which can be used in a plethora of applications. In this work, the synthesis of two types of bis-8-hydroxyquinolines, prepared via either an imination or a Suzuki-Miyaura coupling approach, as well as their analysis is discussed. Imination was pursued through the condensation of quinolinecarbaldehydes with diamines or aminoquinolines with dialdehydes, and the Suzuki-Miyaura coupling reactions were evaluated using a bromoquinoline substrate and diboronic acids. |
| Databáze: | OpenAIRE |
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