Allergic diseases among very preterm infants according to nutrition after hospital discharge
| Autor: | Susanne Halken, Henrik Thybo Christesen, BH Esberg, Jesper Fenger-Grøn, Sven Mortensen, Gitte Zachariassen, J Faerk |
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| Rok vydání: | 2011 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test business.industry Incidence (epidemiology) Immunology Breastfeeding Gestational age Atopic dermatitis medicine.disease Food allergy Pediatrics Perinatology and Child Health Cohort Immunology and Allergy Medicine Respiratory sounds business Breast feeding |
| Zdroj: | Pediatric Allergy and Immunology. 22:515-520 |
| ISSN: | 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2010.01102.x |
| Popis: | To determine whether a cow's milk-based human milk fortifier (HMF) added to mother's milk while breastfeeding or a cow's milk-based preterm formula compared to exclusively mother's milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life. Of a cohort of 324 VPI (gestational age 24-32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA. The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2% and 32.7%, while atopic dermatitis (AD) was 18.0% and 12.1%, respectively. Predisposition to allergic disease increased the risk of developing AD (p=0.04) [OR 2.6 (95% CI 1.0-6.4)] and the risk of developing RW (p=0.02) [OR 2.7 (95% CI 1.2-6.3)]. Boys had an increased risk of developing RW (p=0.003) [OR 3.1 (95% CI 1.5-6.5)]. No difference was found between nutrition groups. None developed food allergy. Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life. |
| Databáze: | OpenAIRE |
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