Immunogenetic parameters in children with atopic diseases
| Autor: | Ya. Yu. Illek, I. G. Suetina, N. V. Khlebnikova, E. V. Suslova, M. V. Savinova, E. V. Dudyreva, E. V. Zemtsova |
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| Rok vydání: | 2023 |
| Zdroj: | Perm Medical Journal. 40:27-33 |
| ISSN: | 2687-1408 0136-1449 |
| Popis: | Objective. To determine the features of the distribution of antigens of the major histocompatibility complex in children of preschool and primary school age with atopic diseases. Materials and methods. Under observation there were children with a moderate course of the diseases such as atopic dermatitis, atopic dermatitis with concomitant persistent allergic rhinitis, independent persistent allergic rhinitis, atopic bronchial asthma. The patients were identified class I and class II antigens of HLA-complex. Results. The studies have shown that patients with atopic dermatitis had a high incidence of HLA B15, DRB1*13 and DQB1*0602-8: in patients suffering from atopic dermatitis with concomitant persistent allergic rhinitis HLA B12, B13 and DQB1 * 01; in patients with independent persistent allergic rhinitis HLA A10 and DQB1 * 201; in patients with atopic bronchial asthma HLA B18. Conclusions. Representation of these antigens of the HLA complex in the tissues was associated with an increase in the risk of atopic diseases by 2.34.6 times. |
| Databáze: | OpenAIRE |
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