1395-P: Maternal Exercise during Pregnancy Affects Offspring Adiposity through One Carbon Metabolism Cycle

Autor:	Ismail Laher, Angela M. Devlin, Arya E. Mehran, Nicha Boonpattrawong
Rok vydání:	2019
Předmět:	One-carbon metabolism Pregnancy Offspring business.industry Endocrinology Diabetes and Metabolism Physiology medicine.disease Obesity Insulin resistance medicine.anatomical_structure Lactation Internal Medicine medicine Weaning business Adverse effect
Zdroj:	Diabetes. 68
ISSN:	1939-327X 0012-1797
DOI:	10.2337/db19-1395-p
Popis:	Maternal obesity during pregnancy can adversely affect adult offspring adiposity and insulin resistance. The goal of this study was to determine if maternal exercise mitigates the adverse effects of maternal obesity on offspring health. Female (C57BL/6NJ) mice were fed from weaning a control diet (10%kcal fat; MC n=18) or western diet (45% kcal fat; MW n=15) to induce excess adiposity. After 13 weeks, the mice were bred and maintained on the diets, with (E) and without (S) access to a running wheel (exercise), throughout pregnancy and lactation. Offspring were weaned onto the control diet and fed for 13 weeks; male offspring were studied. Offspring from MWE dams had greater (p Disclosure N. Boonpattrawong: None. A. Mehran: None. I. Laher: None. A.M. Devlin: None. Funding Canadian Institutes of Health Research
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3eab78838eaeb2167737e6216e48e86 https://doi.org/10.2337/db19-1395-p Zobrazit plný text záznamu