β-d-Ribofuranosyl substituted polyfluoroalkylpyrazoles and their activity against the influenza virus

Autor:	A. E. Ivanova, Vladimir V. Zarubaev, Viktor I. Saloutin, Yanina V. Burgart, Yana R. Orshanskaya
Rok vydání:	2018
Předmět:	010405 organic chemistry Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Chloride Medicinal chemistry Virus 0104 chemical sciences Acetylation medicine Tin medicine.drug
Zdroj:	Mendeleev Communications. 28:52-54
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2018.01.017
Popis:	Regiospecific ribosylation of 3-polyfluoroalkyl-5-phenylpyrazoles with 1,2,3,5-tetra-O-acetyl-β-d-ribofuranose in the presence of tin(iv) chloride followed by deacetylation affords 1-(β-d-ribofuranosyl)-3-polyfluoroalkyl-5-phenyl- 1H-pyrazoles. These derivatives as well as starting pyrazoles were tested for anti-influenza activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3e8fca48e7fab60f550ce18f0651476 https://doi.org/10.1016/j.mencom.2018.01.017 Zobrazit plný text záznamu Full Text from ScienceDirect