Early and late viral infections after lung transplantation
| Autor: | Daniela Libertucci, Massimo Rittà, Filippo Patrucco, Michela Bellocchia, Paolo Solidoro, Cristina Costa, Caterina Bucca, Lorena Mercante, Rossana Cavallo, Massimo Boffini |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Lung medicine.diagnostic_test business.industry Incidence (epidemiology) medicine.medical_treatment Single Center medicine.disease Cystic fibrosis Virus Pneumonia Bronchoalveolar lavage medicine.anatomical_structure Internal medicine Immunology medicine Lung transplantation business |
| Zdroj: | 8.2 Transplantation. |
| DOI: | 10.1183/13993003.congress-2015.pa1801 |
| Popis: | Introduction: Microorganisms involved in lung transplantation (LTx) infections include opportunistic, hospital and community acquired, microorganisms and their time to occurrence after LTx is different. Literature data suggest that the critical period of risk for infections include first six months after LTx. In particular viral infections are related to post transplant morbidity and mortality trough pneumonia, acute and chronic rejection. The aim of this study was to evaluate timing differences of LTx viral infections in our centre. Methods: We retrospectively collected data of consecutive LTx recipients who potentially complete a 24 moths of follow-up from Jan 2010. Bronchoalveolar lavage (BAL) virological data were analyzed: CMV, EBV, HSV1-2, influenza A and B, rhino viruses, HHV6, HHV7, and other respiratory viruses. Follow-up data were divided in 3 period gropus: 0-6, 7-12 and 13-24 month after LTx. Results: We included 49 consecutive patients: 18 underwent LTx for obstructive lung diseases, 20 for fibrosis and 11 for cystic fibrosis. We analyzed 348 BAL. Viral findings were 228. Most frequent virus found were: CMV 92 times, HSV1-2 30, HHV6 26 and HHV7 33. BAL specimens9 positivity were: 120 in the 0-6 group, 64 in the 7-12 and 44 in the 13-24 one. Prevalence and incidence of viral infections were respectively 65,5% and 46,5%. We observed a significant higher prevalence and incidence of virus positivity in the first 6 moths at univariate and multivariate analisys (both with p Conclusions: Our data confirm the criticality of first 6 months post LTx: infact we found higher prevalence and incidence in this period. Our single center study confirms the assumption that viral infections progressively decrease after LTx. |
| Databáze: | OpenAIRE |
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