SY02-4IMPACT OF DOPAMINE DEPLETION OR ENHANCEMENT ON ETHANOL CONSUMPTION IN RATS: FREE VERSUS WORK-MEDIATED ACCESS

Autor: J. D. Salamone, Noemí SanMiguel, L. Monferrer, J. M. Perez-García, J. Camañes, C. Carratalà, Laura López-Cruz, Mercè Correa
Rok vydání: 2015
Předmět:
Zdroj: Alcohol and Alcoholism. 50:i4.1-i4
ISSN: 1464-3502
0735-0414
DOI: 10.1093/alcalc/agv076.07
Popis: Nucleus accumbens dopamine (DA) plays a critical role in behavioral activation and effort-based decision-making. DA depletions reduce the level of effort that an animal is willing to make to obtain a natural reinforcer, but it does not change preference between freely available reinforcers. On the other hand, drugs whose mechanism …
Databáze: OpenAIRE