Potential of Casiopeínas® Copper Complexes and Antituberculosis Drug Combination against Mycobacterium tuberculosis
| Autor: | A R Barbosa, Katiany Rizzieri Caleffi-Ferracioli, Yanis Toledano-Magaña, V L D Siqueira, Fernando Rogério Pavan, C Q F Leite, Lena Ruiz-Azuara, Juan Carlos García-Ramos, R F Cardoso |
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| Rok vydání: | 2016 |
| Předmět: |
Tuberculosis
Drug resistance Pharmacology 010402 general chemistry 01 natural sciences Mycobacterium tuberculosis chemistry.chemical_compound Minimum inhibitory concentration Drug Discovery medicine Pharmacology (medical) Ethambutol biology 010405 organic chemistry Chemistry Isoniazid Resazurin General Medicine medicine.disease biology.organism_classification 0104 chemical sciences Infectious Diseases Oncology Rifampicin medicine.drug |
| Zdroj: | Chemotherapy. 61:249-255 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000443496 |
| Popis: | New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the in vitro activity of Casiopeínas® copper-based compounds (CasIIIia, CasIIIEa, and CasIIgly) alone and combined with isoniazid (INH), rifampicin, or ethambutol (EMB) against resistant and susceptible Mycobacterium tuberculosis. Seventeen clinical M. tuberculosis isolates (5 multi-drug resistant and 2 resistant to INH and/or EMB) were subjected to determination of the minimal inhibitory concentration (MIC) by the resazurin microtiter assay and combination assessment by the resazurin drug combination microtiter assay. The Casiopeínas® alone showed a remarkable effect against resistant isolates with MIC values from 0.78 to 12.50 μg/ml. Furthermore, a synergistic effect mainly with EMB is shown for both resistant and susceptible clinical isolates. Casiopeínas® are promising candidates for future investigation into the development of antituberculosis drugs, being one of the first examples of essential metal-based drugs used in this field. |
| Databáze: | OpenAIRE |
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