Synthesis of spirolactams and spiropiperidines as CCR4 receptor antagonists

Autor:	Brad Newhouse, Christine D. Eberhardt, John Gaudino, Andrew Allen, C. Todd Eary, Shelley Allen, Joshua D. Hansen, Justin G. Schiro, Aaron S. Anderson, Laurence E. Burgess, Ellen R. Laird, David Chantry
Rok vydání:	2006
Předmět:	CCR4 Receptor Stereochemistry Chemistry Organic Chemistry Drug Discovery Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 47:69-72
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.10.139
Popis:	The synthesis of racemic and non-racemic spirocyclic lactams that display high binding affinity toward CCR4 is described. Two distinct series of spirocycles were prepared from the common intermediate 9.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3cbea8ce2daebca9f9cb0f9efcd6391 https://doi.org/10.1016/j.tetlet.2005.10.139 Zobrazit plný text záznamu Full Text from ScienceDirect