Toxicity of the brominated flame retardant (tetrabromobisphenol‐A)
| Autor: | Takahiko Sato, Miki Niikawa, Hisamitsu Nagase, Hideaki Kito, Kazushi Watanabe |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.diagnostic_test
Cholesterol Health Toxicology and Mutagenesis Hematocrit Pollution chemistry.chemical_compound Animal science chemistry Environmental chemistry Brominated flame retardant Toxicity medicine Microsome Environmental Chemistry Tetrabromobisphenol A Blood urea nitrogen Fire retardant |
| Zdroj: | Toxicological & Environmental Chemistry. 55:159-171 |
| ISSN: | 1029-0486 0277-2248 |
| Popis: | The toxicity of tetrabromobisphenol‐A (TBBPA), which is a brominated flame retardant and used in large quantities, was investigated. The threshold for the decrease of body weight was from 0.3 to 3.0 mg/kg/day, and the weight ratio of kidney to body increased from 10 mg/kg/day. The hematocrit value and clotting time decreased, and the cholesterol concentration, blood urea nitrogen (BUN) concentration and choline esterase activity increased. Hemolysis occurred from low concentration (0.5 mg/L) and decreased by metabolization with hepatic microsomal enzyme system. When 500 mg/kg of TBBPA was administrated, TBBPA concentration increased rapidly, but decreased after 4 hr and remained still at 20 hr. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|