An easy access to functionalized allyl dithiocarbamates from Baylis–Hillman adducts in water

Autor:	Vishnu P. Srivastava, Rajesh Patel, Lal Dhar S. Yadav
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Carbon disulfide Chemistry organic chemicals Organic Chemistry food and beverages Biochemistry Medicinal chemistry Coupling reaction Adduct chemistry.chemical_compound Nucleophile Drug Discovery SN2 reaction Stereoselectivity Amine gas treating Dithiocarbamate
Zdroj:	Tetrahedron Letters. 50:1335-1339
ISSN:	0040-4039
Popis:	A facile and direct highly stereoselective synthesis of [ E ]- and [ Z ]-allyl dithiocarbamates has been accomplished from acetates of Baylis–Hillman (BH) adducts in catalyst-free one-pot three-component coupling reactions of carbon disulfide and amine in water under a mild and green procedure with high yields. The reaction pathway involves the nucleophilic displacement (SN2′) of BH acetates by dithiocarbamate anions. The utility of these allyl dithiocarbamates has also been demonstrated in heterocyclic chemistry. © 2009 Elsevier Science. All rights reserved
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3bf66d7a1951c67488e3bb754c96657 https://doi.org/10.1016/j.tetlet.2009.01.023 Zobrazit plný text záznamu Full Text from ScienceDirect