The investigation effect of weight loss on serum vaspin, apelin-13, and obestatin levels in obese individual
| Autor: | Cansu Can Figen, Tevfik Noyan, Ozlem Ozdemir |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Biochemistry (medical) Clinical Biochemistry 030209 endocrinology & metabolism Obestatin medicine.disease Biochemistry Obesity Apelin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Weight loss Internal medicine medicine medicine.symptom business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 45:725-735 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2019-0143 |
| Popis: | ObjectivesIt was aimed to investigate if there were any significant corresponding changes on adipokine levels in obese subjects who achieved a 10% reduction in body weight.MethodsThirty obese and 25 healthy adults were enrolled in present study, and serum levels of vaspin, apelin-13, obestatin, and insulin were determined with the ELISA method.ResultsThe serum obestatin and apelin-13 values of the obese group obtained as basal and after weight loss was significantly lower than in controls (p0.05). The vaspin level did not differ between the groups (p>0.05). The obese group had characterized increased serum insulin and insulin resistance assessment by the homeostatic assay (HOMA-IR) levels compared to controls (p0.05).ConclusionsObese individuals exhibited decreased levels of apelin-13 and obestatin. Moreover, 10% weight loss caused a significant reduction of insulin resistance, but no significant change was detected on apelin-13, obestatin, and vaspin levels. |
| Databáze: | OpenAIRE |
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