ChemInform Abstract: Synthesis of Spiro(4′,5′,10,11-tetrahydro-5H-dibenzo(a,d)cyclohepten-5- yl-2′(3′H)-furans) as Potential Cytokine Inhibitors
| Autor: | Daniel M. Solomon, Pauline C. Ting |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | ChemInform. 26 |
| ISSN: | 0931-7597 |
| Popis: | A synthesis of novel spiro[4′,5′,10,11-tetrahydro-5H-dibenzo[a,d]cyclohepten-5-yl-2′(3′H)-furans] is described. The key reaction was formation of the tetrahydrofuran ring by cyclization of the diol 3 or the protected diol 10. These compounds were investigated as potential TNF-α inhibitors. |
| Databáze: | OpenAIRE |
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