Hypothermia in Experimental Infections: III. The Effect of Hypothermia on Resistance to Experimental Pneumococcus Infection
| Autor: | James D. Hardy, Carl Muschenheim, Dorothy Rhoades Duerschner, Alice M. Stoll |
|---|---|
| Rok vydání: | 1943 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases. 72:187-196 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Fever, though it is one of the most characteristic responses of the animal organism to bacterial invasion, is imperfectly understood and relatively little is known about its r61e in infectious diseases. Inflammatory tissue reactions as observed histologically are more obviously related to resistance and are generally considered to be especially important in localization and destruction of invading bacteria. It has been widely assumed that both general and local temperature elevation in warm blooded animals, whatever the mechanism of its production, assists in the defensive processes of the host. There is direct experimental as well as indirect clinical evidence to support this assumption, but little of it is conclusive and some of it appears paradoxical. It is well known, for instance, that induced fever is beneficial in certain infectious diseases and not in others, but in those diseases in which it is beneficial its action appears to be by direct thermal destruction or inhibition of the infectious agent rather than by any enhancement of the normal defensive mechanisms of the host. It has also been a common observation that where resistance is |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|