Synthesis of fluorinated carbocyclic nucleosides: preparation of (±)-carbocyclic-FMAU and some congeners

Autor:	Les Stephenson, Anne M. Exall, Alexandra M. Z. Slawin, Peter Youds, Barrie E. Kirk, Alan D. Borthwick, Stanley M. Robberts, K. Biggadike, Derek Evans, David J. Williams
Rok vydání:	1987
Předmět:	chemistry.chemical_classification Trifluoride Ketone Bicyclic molecule Chemistry Crystal data X-ray crystallography Molecular Medicine Organic chemistry Molecule Crystal structure
Zdroj:	J. Chem. Soc., Chem. Commun.. :251-254
ISSN:	0022-4936
DOI:	10.1039/c39870000251
Popis:	The alcohols (7) and (19) and the ketone (28) were treated with diethylaminosulphur trifluoride (DAST) to give the fluoro-compounds (8), (21), and (29) respectively: compound (8) was converted into the potential anti-viral agents carbocyclic-FMAU (14) and carbocyclic-FIAU (16) white compound (21) afforded the 2′-α-fluoro-carbocyclic nucleosides (24), (25), (27), and compound (29) gave the difluoro-analogue (32)[crystal data were obtained on compounds (8) and (9)].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3af06388f5e8bc0c265669d10fc4e88 https://doi.org/10.1039/c39870000251 Zobrazit plný text záznamu