C28 Terpenoids from Lamiaceous Plant Perovskia scrophulariifolia: Their Structures and Anti-neuroinflammatory Activity

Autor:	Kanji Niwa, Kohji Itoh, Yoshiki Kashiwada, Naonobu Tanaka, Nilufar Z. Mamadalieva, Daisuke Tsuji, Seita Kajihara
Rok vydání:	2020
Předmět:	biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Carbon skeleton 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry Terpenoid 0104 chemical sciences Moiety Lamiaceae Perovskia scrophulariifolia Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 22:7667-7670
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c02855
Popis:	Structurally unique C28 terpenoids, perovsfolins A (1) and B (2), were isolated from the aerial parts of an Uzbek medicinal plant, Perovskia scrophulariifolia (Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C6-C3 ester moiety were elucidated on the basis of spectroscopic analyses aided by density functional theory calculations as well as chemical evidence. Perovsfolin B (2) exhibited an anti-neuroinflammatory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3ae29444a917a842739b783a0b00b9c https://doi.org/10.1021/acs.orglett.0c02855 Zobrazit plný text záznamu