Wirksamkeit, Verträglichkeit und Praktikabilität von Valproat-Miniretardtabletten bei bipolaren affektiven Störungen
| Autor: | Benedikt L. Amann, L. Schaerer, Andrea Sterr, Martin Schäfer, E. Wild, J. Walden, Heinz Grunze |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Drug
Exacerbation business.industry media_common.quotation_subject Acute mania medicine.disease behavioral disciplines and activities Manic symptoms Psychiatry and Mental health Neurology Rating scale Anesthesia mental disorders medicine Neurology (clinical) Bipolar disorder medicine.symptom business Mania Depression (differential diagnoses) media_common |
| Zdroj: | Fortschritte der Neurologie · Psychiatrie. 68:496-502 |
| ISSN: | 1439-3522 0720-4299 |
| Popis: | UNLABELLED Valproate has recently emerged as a drug of first choice in treating acute mania because of its efficacy and relative safety. It can be administered as an intravenous, oral non-sustained release or oral sustained release loading therapy. A new sustained release formulation of valproate consists of "mini-tablets" with the possible advantage of a less problematic and more reliable administration of the drug. We report on eleven patients with an acute manic exacerbation who were investigated for sufficient control of manic symptoms and the duration of building up and maintaining sufficient blood levels of valproate in once/d versus twice/d administration of valproate delayed release mini-tablets (VPA mrt.). Acute and prophylactic effectiveness in mania were rated with the Young-Mania Rating Scale (YMRS), respectively the Global Clinical Impression Scale for Bipolar Disorder (CGI-BP). RESULTS Within a short period of time sufficient blood levels in both groups (once/d versus twice/d administration) were built up. Seven of eleven patients were responders according to a reduction of 50% of the YMRS. In respect of prophylactic treatment all of the ten patients showed satisfactory results and no re-exacerbation of manic symptoms or depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|