Biofunctional Effects of Thiohemiaminal-Type Dimeric Sesquiterpene Alkaloids from Nuphar Plants
| Autor: | Hisashi Matsuda, Masashi Fukaya, Seikou Nakamura, Masayuki Yoshikawa, Souichi Nakashima |
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| Rok vydání: | 2019 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Hydroxy group General Chemistry General Medicine 010402 general chemistry biology.organism_classification Sesquiterpene 01 natural sciences 0104 chemical sciences Rhizome chemistry.chemical_compound chemistry Apoptosis Cell culture Drug Discovery Neothiobinupharidine Nuphar Plaque forming cell |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 67:666-674 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Dimeric sesquiterpene thioalkaloids from the rhizomes of Nuphar pumilum exhibited immunosuppressive effects using a sheep erythrocyte plaque forming cell (PFC) assay, as well as an anti-metastasis effect, and rapid apoptosis-inducing effects in tumor cell lines. In particular, dimeric sesquiterpene thioalkaloids with a hydroxy group (6-hydroxythiobinupharidine, 6,6'-dihydroxythiobinupharidine, 6-hydroxythionuphlutine B) showed substantial effects, whereas dimeric sesquiterpene thioalkaloids lacking the hydroxy group (thiobinupharidine, thionuphlutine B, 6'-hydroxythionuphlutine B, neothiobinupharidine, thionuphlutine B β-sulfoxide, neothiobinupharidine β-sulfoxide) and monomeric sesquiterpene alkaloids (nupharidine, 7-epideoxynupharidine, nupharolutine) showed weak activity. In this review, we summarize our studies of the biofunctional effects of these alkaloids. |
| Databáze: | OpenAIRE |
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