NMR spectroscopy for assessing cocaine-functional monomer interactions when preparing molecularly imprinted polymers
| Autor: | Jesús Sanmartín, Pilar Bermejo-Barrera, Ángeles Peña-Gallego, Ana María Bermejo, Juan Sánchez-González, Antonio Moreda-Piñeiro |
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| Rok vydání: | 2019 |
| Předmět: |
010401 analytical chemistry
Molecularly imprinted polymer 02 engineering and technology Nuclear magnetic resonance spectroscopy Nuclear Overhauser effect 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Monomer chemistry Polymerization Methacrylic acid Polymer chemistry Proton NMR Molecule 0210 nano-technology Spectroscopy |
| Zdroj: | Microchemical Journal. 147:813-817 |
| ISSN: | 0026-265X |
| DOI: | 10.1016/j.microc.2019.03.088 |
| Popis: | Synthesis of molecularly imprinted polymers (MIPs) implies a previous pre-polymerization stage in which the template (the molecule for which the MIP offers the specific recognition cavities) interacts with the adequate functional monomer, just before the addition of the cross-linker and the initiator for performing the polymerization synthesis. The recognition properties, as well as the physical properties of the prepared MIP beads, are dependent on the successful template-monomer interaction during the pre-polymerization stage. Investigations by proton nuclear magnetic resonance (1H NMR) and nuclear overhauser effect (NOE) were performed to study the interactions between the template (cocaine) and the monomers (methacrylic acid and ethylene dimethacrylate). Experimental results were additionally compared to those obtained by in silico studies. |
| Databáze: | OpenAIRE |
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