Adult Metachromatic Leukodystrophy

Autor:	H.H. Goebel, A. Argyrakis, H. Pilz
Rok vydání:	1977
Předmět:	Pathology medicine.medical_specialty Adult metachromatic leukodystrophy Leukodystrophy Metachromasia Skeletal muscle Anatomy Biology Sural nerve biopsy medicine.disease complex mixtures Lipofuscin medicine.anatomical_structure Neurology Peripheral nerve medicine Ultrastructure Neurology (clinical)
Zdroj:	European Neurology. 15:308-317
ISSN:	1421-9913 0014-3022
Popis:	Sural nerve biopsy in a 44-year-old woman with adult metachromatic leukodystrophy (MLD) confirmed by deficient arylsulfatase-A activity, showed a reduction in the number of large and small myelinated axons, and sparse metachromatic material. Ultrastructurally, the latter consisted of various types of residual bodies including the tufaceous and prismatic forms typical of MLD. In the striated muscle, large amounts of regular lipofuscin but no MLD-characteristic inclusions were encountered. Inclusion-bearing mitochondria in the muscle appeared to be an incidental finding.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b3939155f4f092325332b9f681d0b50c https://doi.org/10.1159/000114819 Zobrazit plný text záznamu