PL02 Obtaining a Suitable Analyte from Deceased Tissue Donors for a Potential vCJD Test
| Autor: | S. Poniatowski |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Transfusion Medicine. 16:1-1 |
| ISSN: | 1365-3148 0958-7578 |
| DOI: | 10.1111/j.1365-3148.2006.00693_2.x |
| Popis: | There is much current interest in the development and validation of a suitable blood test that could be used to screen all donors to avoid potential vCJD transmissions. In the interim there are other ‘tissues’ where abnormal prion could be assayed including those of the central nervous and lymphatic systems. Tonsil and spleen biopsies assessed for abnormal PrP are thought to be possible early indicators of infectivity. Although it is not reasonable to routinely obtain these biopsies from living blood donors, clearly there is a potential to obtain these tissues from donors who are deceased with appropriate consent. There are however problems associated with obtaining this tissue including the impact of the post-mortem investigation into cause of death, expertise in locating the tissue and the effects of rigor mortis. Also, given the assay result turnaround time, there are further complications associated with managing a positive test result including where organs or tissues from the donor have already been transplanted. These issues limit the suitable donor pool. The result is that only 25–50% of deceased tissue donors are indeed suitable. This population is being tested as a pilot within the NBS as a potential risk reduction measure. |
| Databáze: | OpenAIRE |
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