Perivascular CSF flow in the rat cerebellum

Autor:	Nigel R. Jones, R. R. Kumari, Marcus A. Stoodley, J. S. Dhaliwal
Rok vydání:	1999
Předmět:	Cerebellum business.industry General Medicine Anatomy Granular layer Cisterna magna Fourth ventricle White matter medicine.anatomical_structure Cerebrospinal fluid Neurology Physiology (medical) Medicine Surgery Neurology (clinical) Subarachnoid space Perivascular space business
Zdroj:	Journal of Clinical Neuroscience. 6:143-146
ISSN:	0967-5868
Popis:	Cerebrospinal fluid (CSF) flow from the subarachnoid space into the cerebellum was studied in rats using Horseradish peroxidase (HRP) injected into the cisterna magna. Animals were sacrificed after 0, 10 or 30 min Transpial diffusion of HRP did not extend beyond the Purkinje cell layer. At all time intervals, perivascular spaces labelled with HRP were observed in cerebellar grey and white matter. In the cerebellar granular layer and white matter, HRP was usually present only in perivascular spaces and the surrounding extracellular space. There was no evidence of a preferential flow towards the fourth ventricle. These results suggest that there is a perivascular pathway for rapid flow of CSF from the subarachnoid space into the perivascular spaces and then into the cerebellar extracellular space. The Purkinje cell layer appears to act as a barrier to diffusion from the pial surface.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b388995fab10d89c98b80c5409dffc7a https://doi.org/10.1016/s0967-5868(99)90080-2 Zobrazit plný text záznamu Full Text from ScienceDirect