HISTOLOGICAL CHANGES FOLLOWING OVARIECTOMY IN MICE

Autor:	Clarence Cook Little, George W. Woolley, Elizabeth Fekete
Rok vydání:	1941
Předmět:	medicine.medical_specialty business.industry medicine.drug_class Regeneration (biology) Immunology Uterus Strain (injury) Hyperplasia medicine.disease medicine.anatomical_structure Endocrinology Estrogen Internal medicine medicine Vagina Ovariectomized rat Immunology and Allergy business Hormone
Zdroj:	Journal of Experimental Medicine. 74:1-8
ISSN:	1540-9538 0022-1007
DOI:	10.1084/jem.74.1.1
Popis:	1. In dba mice ovariectomized at birth the vagina, uterus, and mammary glands showed a gradual recovery from the castrate state, and finally reached the stage which they presumably can attain only under the influence of estrogenic hormones. Tumors of the mammary glands developed in 37 animals, of 75 examined, between the ages of 14 and 28 months (3 adenomas and 34 carcinomas). 2. As ovarian regeneration had not taken place the probability that estrogen originated in some other organ in the absence of the ovaries is suggested. 3. The consistent nodular hyperplasia of the suprarenal cortex and close morphological similarity of cells of these nodules to lutein-like cells of the ovaries points to the abnormal suprarenals as possible sources of the estrogenic hormones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b38384b275c1e1c4f6da34e038bb17da https://doi.org/10.1084/jem.74.1.1 Zobrazit plný text záznamu