Minipigs: Applications in Toxicology

Autor: Alain Stricker‐Kongrad, Guy Bouchard, Larry D. Brown
Rok vydání: 2013
Předmět:
Zdroj: Current Protocols in Toxicology
ISSN: 1934-9262
1934-9254
DOI: 10.1002/0471140856.tx0111s56
Popis: Minipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology studies. Acute, subchronic and chronic studies are possible using all routes of administration. Minipigs have distinct size advantages over domestic pigs. There exist some minor limitations with minipigs, but for the most part they offer well correlated models to humans for dermal and systemic toxicology assessments. Phototoxicology and reproductive toxicology usage is expanding. Minipig size, anatomy, physiology, metabolism, and genetics generally correlate well to human factors. The minipig makes an appropriate model for toxicology. Curr. Protoc. Toxicol. 56:1.11.1-1.11.19. © 2013 by John Wiley & Sons, Inc. Keywords: minipig; toxicology; animal model
Databáze: OpenAIRE
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