Chemoenzymic synthesis and biological activity of both enantiomeric forms of tetraconazole, a new antifungal triazole

Autor:	Garavaglia Carlo, Pietro Cesti, Sandro Spezia, Luigi Mirenna, Daniele Bianchi
Rok vydání:	1991
Předmět:	Chemistry Stereochemistry Triacylglycerol lipase Triazole Ether Biological activity General Chemistry Transesterification Hydrolysis chemistry.chemical_compound Organic chemistry Stereoselectivity Enantiomer General Agricultural and Biological Sciences
Zdroj:	Journal of Agricultural and Food Chemistry. 39:197-201
ISSN:	1520-5118 0021-8561
DOI:	10.1021/jf00001a040
Popis:	Both enantiomers of (R,S)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether (tetraconazole), a new, broad spectrum, triazole fungicide, were prepared by stereoselective lipase-catalyzed hydrolysis of the racemic precursor (R,S)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)-prop-1-yl acetate or by lipase-catalyzed transesterification of the prochiral precursor 2-(2,4-dichlorophenyl)-1,3-propanediol (.)
Databáze:	OpenAIRE
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