Effects of a novel class III antiarrhythmic agent, CPUY11018, on rat atrial fibrillation

Autor:	Qidong You, Chun-Lin Chen, Qian Yang, Yue-Miao Yin, Yiqun Tang, Xiang Guo
Rok vydání:	2010
Předmět:	Fibrillation medicine.medical_specialty Chemistry Depolarization Atrial fibrillation Pharmacology medicine.disease Class III antiarrhythmic agent Delayed rectifier Internal medicine Drug Discovery medicine Cardiology Patch clamp medicine.symptom After treatment Acetylcholine medicine.drug
Zdroj:	Drug Development Research. 71:303-312
ISSN:	0272-4391
DOI:	10.1002/ddr.20375
Popis:	CPUY11018 has anti-atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K+ current (Ito) and ultra-rapid delayed rectifier K+ current (IKur) were studied using whole-cell patch clamp techniques and an acetylcholine (ACh)-CaCl2 induced AF model. CPUY11018 inhibited Ito and IKur in a concentration-dependent manner with IC50 values of 18.5 and 1.7 µM, respectively. Inhibition was independent of the depolarizing voltage. In the AF ACh-CaCl2 model, AF duration was effectively shortened after treatment with 5 mg/kg CPUY11018 for 4 days. These results indicate that CPUY11018 is effective in treating AF partly by blocking Ito and IKur. Drug Dev Res 71, 2010. © 2010 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b37984022ec55c37d60597bcc4513da0 https://doi.org/10.1002/ddr.20375 Zobrazit plný text záznamu Plný text